For me it's easy.
I played Mass Effect 1 and thought it was great!! The moment i became a spectre, wow.
Then i drove the MAKO for the first time. Ouch, wat a bummer that was. I couldn't handle it. The controls, the way the thing drove around on the planets. For me it felt like the ultimate dealbreaker~!!!
I almost didn't play the game anymore, but luckily the story was just too intense to let go.
So what's yours???