Uncharted: Drakes Fortune
Uncharted 2: Among Thieves
Uncharted 3: Drakes deception
Uncharted could basically be about Francis Drake. This would give the franchise somewhat of a "freshness" and allow them to somewhat do something differently but still keep the core experience.
I fully trust ND on whatever they want to do. However I obviously hope to see the old cast back, though. Drake and Sully in my heart. Fingers crossed for more at VGAs