Pokemon Black and White really comes to mind here. I just could not get into that game at all. I blame Pokemon Mystery Dungeon for that because it's just a better series.
Another is Skyrim for PS3. On PC it's great, but the game just hates me on PS3 and froze on me 5 times within the first hour. Needless to say, I threw my controller and haven't looked back. Just another reason why I PC game now.