Too many to name, but I'll list my top 5.
1. Devil May Cry 2 - The first game had great gameplay and was challenging, but the second one was incredibly easy. Dante Must Die mode in DMC2 is easier than the normal mode of DMC1. Boss battles were terrible; you can easily spam bullets/rockets during a boss battles. Also, the weapon selection was terrible. The only good thing about the game was the soundtrack.
http://www.youtube.com/watch?v=WTqjpFWP20w
2. Yoshi's Story - I loved Yoshi's Island; it's one of my favorite games of all time. And I was expecting Yoshi's Story to be just like YI, but nope, it was entirely different. Too easy, too short, having to eat 30 fruits to end a level was lame, and the songs the Yoshis would sing after beating a level was embarrasing to hear.
3. Metal Gear Solid 4 - I did a whole thread on it. gamrconnect.vgchartz.com/thread.php?id=139962
4. Uncharted 3 - I loved the second game, but I found the third one boring. It's too scripted. You don't even get to shoot anyone in the first hour or so. Speaking of shooting, the aiming and shooting mechanics were terrible. I don't remember them being this bad in U2. There are too many chase/running away sequences, like 11 of them I think. It's an overkill and gets annoying after a while. Hated that they forced melee combat numerous times. Melee isn't very good at all and pales in comparison to Batman. Bonuses and tweaks were absent which lowered the replay value. Desert scene was incredibly dull; all they had you do there was walk for fifteen minutes until it was over. BORING! End boss 'fight' was laughably bad; you didn't even have to do anything, just counter his attacks. And it was lazy on ND's part to end the game the same way U2 ended - "falling city."
5. Grand Theft Auto 4 - There was a lack of variety in missions which made the game repetitive and boring. Driving was terrible. Gameplay was too clunky. Cell phone system was annoying. If you declined a call, your relationship goes down, and if you turned off your cell phone, you couldn't progress because some missions are given to you through your cell phone.