It's been quite a while since we had one of these, and profile pictures do change over time.
So, select a category from the poll, and then tell us specifically what's in your avatar.
Mine was Wheatley, from Portal 2 (which is, of course, a game).
EDIT: The more astute among you may have noticed that my profile picture is no longer Wheatley. That would be Vernon Roche from The Witcher 2, the review of which you can read here.