Just some random guesses...

-Tales of Graces published by Nintendo in America/Europe this fall.

-Level-5 to start selfpublishing in the west with Inazuma Eleven.  Professor Layton and the Unwound Future to be their last Nintendo published title.

-Golden Sun sequel moved to 3DS.

-US 3DS launch November 2010.  F-Zero and Wario Ware launch games.

-Virtual Console Express for 3DS.  GB/C games for 500 points, GBA for 800.  3rd party formats tba.

-Vitality Sensor no show.   Being reworked for next gen.

Wouldn't that be an announcement that Level 5 would put up themselves? Why would that go in Nintendo's show?

Let´s see,,,,

Wii

- Zelda wii
- vitality sensor with wiirelax & a few more games
- Pikmin 3
- Xenoblade dated
- last story dated
- retro studio´s game...
- kid icarus wii someone?...
- wii party...
- kirby wii

DS:
Golden sun dated
fire emblem dated
new advance wars (hopefully)
new yoshi story game
pokemon dated

DS3:
mario games...
nintendogs, cats, pets....

Unknown platforms


- new star fox (2011)
- Donkey kong 4 (Q42010) ;)
- f-zero
- new paper mario
- super mario rpg remake (one can dream ;)


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how can unanounced prijects be an actual prediction? O_o

I don't expect anything else big being announced for 2010 for the Wii, well except the almost already confirmed LOZ and Wii Relax. With these 2 games TLS, Xenoblade, Wii Party and possibly the localisation of Reginleiv that's already a lot for this year. Perhaps eventually Kirby in Japan but that's all.

For 2011 I totally expect Starfox to be unveiled with the same kind of controls as the plane game in WSR, which means requiring WM+. Perhaps TPS and lightsaber parts will be added too. Probably 1 or 2 big new games by Retro (if they don't work on SF) and Project Sora. One of them will use the Vitality Sensor.

I don't think we will see Pikmin 3 : I think the aesthetic of this serie would be great with very realistic graphics like the clay based artworks so I think it will be a launch title for Wii 2. I really hope I will be proven wrong though because Pikmin 1/2 NPC were amazing but I'm not sure they could add anything significant enough in a sequel for the Wii.

As for third parties I expect not a lot of games but big ones at least from Square and Rockstar and yes possibly from Capcom. At least SSF4 has to be released on Wii too.

The kind of games I would like them to show even if they obviously are totally wild guesses:
- A Mario Tennis/Strikers/Golf/Baseball all-in-one game. Possibly a paintball multiplayer mode added too. That would sell amazingly well much better than separate games combined imo: all the WSR fans would buy it while the concept is still different, laying the emphasis more on crazy items instead of realistic motion controls. They of course could re-used a lot of the assets (characters, environments...) for each sport.
- A Mario detective game in the same vein as Disney Guilty Party taking place in Wuhu Island. Miyamoto talked about something like that and that would be great.
- A Pilotwings game using the balance board.

For 3Ds I expect the last feature to be 3D pointing as I have already said several times.

Doctor Who

Maybe they'll piggyback Nintendo for distribution or something?  I can't imagine they'd want to selfpublish PSP games in the US at this point anyway... their big focus is probably going to be the Inazuma Eleven games, the 2nd Layton trilogy and Nunokuni anyway.

Anyway, I think Nintendo will have all the following localizations present in their lineup for release through spring 2011...

Wii

• FlingSmash! (Artoon)
• Kirby's Dream Land 4 (HAL Laboratory)
• Metroid: Other M (Nintendo SPD / Team Ninja)
• PokePark Wii: Pikachu's Adventure (Creatures Inc.)
• Samurai Warriors 3 (Omega Force)
• Sin & Punishment: Star Successor (Treasure Video Games)
• Tales of Graces (Namco Tales Studio)
• The Last Story (Mistwalker / Artoon)
• The Legend of Zelda (Nintendo EAD)
• Wii Party (Nintendo EAD)
• Wii Vitality (Nintendo EAD)
• Xenoblade (Monolith Soft)

Kinda just posted most of this in another topic but oh well:

Wii Party
Wii Vitality Detailed and Wii Relax Unveiling
Maybe one or two other Vitality Sensor games
Pikmin Wii
Zelda Wii
More info about some 3rd party titles such as Zangeki, Tales of Graces, Epic Mickey, Last Story, Xenoblade, Conduit 2, etc.
Possibly a few more Wii games unvealed such as Kirby Wii, Star Fox, Kid Icarus, Star Wars Rogue Squadron - some of which or all w/ motion plus support, possible tacked on Vitality Sensor support for some as well.

Golden Sun DS
Pokemon Black and White
Dragon Quest XI more info

and of course..
3DS unveiling with game trailers and demonstrations - new feature also unveiled (maybe motion sensing)
possible Mario Galaxy 3DS? O_o
New Trauma Center
Professor Layton
Mario Kart
Sonic

I think that Rockstar is going to surprise us with something cool at E3 on the Wii...