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You can kill every character in The Outer Worlds
https://www.pcgamer.com/you-can-kill-every-character-in-the-outer-worlds/
Speaking to Polygon, Obsidian's senior designer Brian Heins confirmed that in The Outer Worlds, you'll be able to kill anyone you want. And to protect your ability to complete quests, there are back-up systems in place.

Great, Obsidian sticking to old RPG design philosophies.