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deskpro2k3 said:
so can i do a rig with an AMD cpu and a nvidia graphic card? any downside with that combination?

Yes. None that I can think of.

@OP

I have a Radeon 280. Currently, I'd recommend an Nvidia card especially in the enthusiast range. If you're a cheapskate like me, then you will continue to get mid-high end Radeon cards.