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NightlyPoe said:

That's actually not correct.  In terms of the Senate, which the only one that matters for nominations other than VP, Clinton and Eisenhower are the only two presidents in modern times to lose a Senate majority after their first midterm.  Before that you have to go back to Cleveland's second time being president and Hayes.

For some reason I had remembered Bush Sr. and Obama losing control of the senate during their initial mid-terms, but it looks like you're right - the former never had control of the senate to begin with, while it was the latter's second mid-terms where that happened.