I'm not a big anime person, but I've seen some as they went across Cartoon Network, and I've watched some on my own too.
My top 5 I guess are:
Rurouni Kenshin - This was basically the first anime I watched on a regular basis, and it still sticks to me now...it was very good.
Trigun - I saw a few episodes a long time ago, then watched them all a few years ago...it was very cool. The main character Vash was just amazing.
Samurai Champloo - I dunno...it was just cool.
Death Note - Amazing! I didn't read the manga or anything...I don't really read manga...but the anime was so well thought-out and put together...it got me and a fair number of non-anime-watching friends hooked.
Cowboy Bebop - I absolutely love this series. I can watch it anytime...I love it.
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Bet with disolitude: Left4Dead will have a higher Metacritic rating than Project Origin, 3 months after the second game's release. (hasn't been 3 months but it looks like I won :-p )