Genetical gender is not the same as "mental" gender (I don't know what's the correct phrase in English xDD). You could be a man, and still feel like a woman, and viceversa. We have to be supportive and seeing this as something normal (it IS something normal, you know what I mean), so they could integrate into society easily, not with some pricks and assholes insulting them and bulliying them, which, sadly, happens way too much.