-Destiny is hardcore FPS.
-Portal 2 is smaller game than Mass Effect 3 and Deus Ex.
-Yes, but Crysis 3 was simple Wii U port, this title is a complete rework of the old game not just a remastered, game was in work more than 2 years in work. Maybe its moved for NX, but I don't think it completely canceled. Also, Project Cars for Wii U is very likely moved for NX like Slithly Mad Studios said.
-Saying all that, TP HD fits pretty good with infos we have about Tantalus project.
-Destiny is rated T and not hardcore. What about it makes it hardcore? Not all shooters are hardcore...
-The game itself does not have to be huge. If they are doing a remaster of portal 2, then that can still be considered their biggest project seeing as how it's better than a simple port (mass effect 3 and deus ex)
-Once again, there is nothing stopping the game from being canceled. This may be hard for you to hear, but it is very much a possibility given (a) wii u's install base (b) wii u's audience ( c ) internal development issues
and yes, TP is a possibility, albeit not a very strong one given that we already had a wind waker, ocarina of time, and majora's mask remake this gen.