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Nightmare Frontier is the Blighttown of this game...It is so annoying to deal with projectiles boulders 1 hit kill, crazy bitch who gets you frenzied, plus the swamp that poisons you and makes it harder to run from the two previous points. Add on top of that cliffs and enemies pushing you off the cliff. It's a rage inducing stage.

 

EDIT: FInally beat the boss. It was hectic because my co-op died within seconds and when I got to half her hp, my vials were done. Damn, the adrenaline.