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The 295X2 is far beyond the call of duty (pun intended) and it is a waste if you are not running ultra HD Monitor that can provide the res this card can crank out so if money isn't the issue, first consider what it is you are trying to achieve and what you will be viewing it on.

Also, and especially for AMD and the 290x and 295X2 be sure not to skimp on quality PSU and shoot for Gold cert at the minimum to max power efficiency.

Finally, as counterintuitive as it seems, select a case that fits the airflow, additional cooling and space you will require for the parts inside. Personal I adore Cooler Master but you have tons of choices.

Happy Rigging!