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Of course it "can" run those. EA tried FB2 on WiiU, they just said they didn't get good results from it.
It's the same as UE4 actually. It works, but it wouldn't be worth it for Epic, since the end result wouldn't be drastically different to UE3.5.

Also there is no Wii game that uses the Glacier 2 engine. The first and so far only game that uses that engine is Hitman Absolution.