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Massive difference. They opened the door for Sony by choosing cartridge. Final fantasy, resident evil, metal gear, and possibly tomb raider would have come to the 64. Cartridges vs CD were deciding factors for developers back then because of the expense and limitations of cartridges, CD's were a no brainer to develop games on. Ps1 sold so well on the strength of 3rd party support. Choosing cartridge over CD was the beginning of the end for nintendos strong 3rd support.