I think Move controls worked great in inFamous 2. So I don;t see why they couldn't have worked in Uncharted 3. Mostly, it would be because of having to retro programme Move functionality and it wasn't part of the original design work. Not because there's a fundamental gameplay incompatibility. inFamous 2 had Move controls retro-fitted, and while it lacked fine tuning options to suit each gamers preferences it worked very well and I don't play inFamous 2 with std controls any more.
I can see, with the likely scarecity of bullets in the game, that you'll need to use a heavy pipe, or other hand weapons a fair bit. And we already know Move is great for swordplay simulation.
“The fundamental cause of the trouble is that in the modern world the stupid are cocksure while the intelligent are full of doubt.” - Bertrand Russell
"When the power of love overcomes the love of power, the world will know peace."
Jimi Hendrix
