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I've been a fan of "confuzzled" myself. A mixing of confused and puzzled. Just like befuddled they're all quite close in meaning, and the merging into new terms is just a fun way to express the same meaning.

Rocket science and brain surgery are obviously not the same thing, but they're both expressions used to explain something that is quite complicated, or something very simple when used after a negative. I'm also a fan of "rocket surgery" and sometimes it'll spark a couple of laughs if used in conversation.