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playing Mass Effect 2 for the second time and beating it on PS3(having already played and beaten ME2 on my 360 twice as well) I've noticed that whenever I use Garrus and Thane shit gets done quick, specailly after getting all the upgrades(weapons and shielding) and their loyalty powers, I hardly even need to command them to use their powers.(maybe a mix if good AI and an overall skill set)

other good combinations in my opinion:(on a side note: I've used the soldier class for all my playthroughs)

Miranda&Jack

Miranda&Jacob

Garrus&Grunt

Katsumi&Legion

Thane&Katsumi

Worst team:

Mordin&Samara(they just always get mowed down by practically every enemy)

Zaeed in general( I find is techniques to be quite ineffective...maybe I'm not using him right)

you don't have to limit yourselves to just Mass Effect 2(though PS3 owners will)