Lesson 1: Use licensed I.P. Check! Notice how the game sold in the U.S. compared to the E.U where Mickey is far more popular than in Europe?
Lesson 2: Good game design is paramount no matter what innovation you want to bring to the table.
Lesson 3: Legendary game designers can do well on any game system. Hire more of them. (If you can)
Lesson 4: A game worth buying is a game worth marketing.
Lesson 5: Wii titles do well if they have important keywords like 'Party, Dance, Epic, Wii, Mario' in them. Try to make up your title with as many as reasonably possible. In this case we have 'Epic' and 'Mickey', Mickey being almost as well known as Mario these days in the U.S. sure helps.