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If you're going to play ToS, play the first ToS that's on the Gamecube. ToS: Dawn of the New World is a direct sequel.

I haven't played the other two, so I can't judge those, but ToS should be an amazing game. My friend is extremely addicted to Tales games (especially Symphonia) and he's put hundreds of hours into that game.

There is one thing I'd like to point out, ToS is going to be extremely different from the other two games, at least Harvest Moon. I'm not entirely sure what Rune Factory is like, but Harvest Moon is about as close to ToS as the Legend of Zelda is to Mario.