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it's not 1 definate reason that kills in those cases ...

The primary thing is stress hormones .. those are lethally poisonous .. usually in the dosis the body produces them they only increase the heart rate by a bit , but the excitement one feels from gaming can lead to a constant output of stress-hormones , which are a huge burden on the blood ciculation and especially the heart ..

In most cases the people don't die ,when they are playing , but when they decide to rest after such a 2-4 days gaming marathon. The sudden drop in the hormon level makes the fatigue on the heart suddenly show up and it can't keep it's rythm anymore , so that people usually die from a cardic arrest , if they can't get revived within some minutes .


A second reson can be embolism - in sitting position , especially when all cramped up (like often in gaming situations) small blood cristals can be formed in the leg veines , which usually are attached to the vescular wall , but if they get dettached and travel through the veines they reach the heart and after that the lunges and can block very very essential arteries. And ofcourse when a certain amount of the lunge or the brain (which they reach after the lunges) gets blocked it's a major and life threatening situation.
The danger of this happening increases by a huge amount ,if people don't drink enough / are already quite dehydrated.


Ofcourse depending on the person there can be even more dangers , but those two are the main reasons for dieing while/after gaming for a far too long time in my opinion.