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I've played the PS2 version. I've only seen videos of the Wii version, but I think the solid FPS and actual crosshairs on the screen for your weapons instead of the Gamecube's and PS2's small red laser is better for aiming.

Apart from that though, I wasn't a big fan of RE4 and lack of movement and sight annoyed me. While it could create tension, I don't like the fact that I have to fumble with the controls for the game to be scared and it gets frustrating very quickly.

You'll get used to the controls though and you'll eventually be able to know how to be more aware and how to react to enemies. Still, it's rough at the beginning.