1. Super Mario Galaxy;
2. Metroid Prime 3: Corruption;
3. Resident Evil 4: Wii Edition;
4. The Legend of Zelda: Twilight Princess;
*EDIT: Since Cougarman is doing it, honorable mentions: No More Heroes, Fire Emblem: Radiant Dawn, Resident Evil: Umbrella Chronicles.
Random game thought :
Why is Bionic Commando Rearmed 2 getting so much hate? We finally get a real game and they're not even satisfied... I'm starting to hate the gaming community so f****** much...